Jason Zhang Grade 12 student at Bayview Secondary School, Sun Life Gene Medical Science Institute Cancer Research Program Student, Toronto, Ontario, Canada 

Abstract SH3-domain kinase binding protein 1(SH3KBP1) also known as CBL-interacting protein, 85-KD/CIN85, functions as an adaptor protein. It is involved in multiple immune functions, expressed in immune organs and cells, specifically in the activation of B cells, the production of antibodies, and the activation of NFKB, following stimulation from B-cell receptors. It also plays a role in the prevention of EGFR degradation through the autophosphorylation of EGFR receptor sites. SH3KBP1 is also linked with other conditions, such as X-linked agammaglobulinemia. It shows its presence in other oncogenic activities, such as presence in glioblastomas and breast cancer, through overexpression via EGFR signaling and cell invasion. This review will discuss the role of SH3KBP1 in cancer development, tumor microenvironment, and potential therapeutic targeting. Keywords: SH3KBP1/ CIN85/ 85-KD, SH3, adaptor protein, cancer development, therapeutic targeting